The skin’s immune system is our first line of defence against invading pathogens. In certain conditions this protective system can act in an uncontrolled way, leading to skin inflammatory conditions. Prof Graham Ogg of the MRC Human Immunology Unit is studying an inflammatory skin disease called atopic eczema (or atopic dermatitis). “Atopic eczema affects 20-30% of children and 5-10% of adults in the UK. It is related to other allergic diseases such as asthma, hay fever and food allergies, which collectively carry an enormous burden on patients and their families”, says Prof Ogg. “If we can understand the pathways of disease in atopic eczema then we may be able to identify new routes to treatment”.
![Graham Ogg Graham Ogg and Clare Hardman – first author on the paper](https://www.rdm.ox.ac.uk/images/news/graham-ogg/@@images/43d81506-23a2-4972-a056-711980ca5892.jpeg)
Using this technique, the researchers showed that ILC2s are able to interact with CD1a-reactive T cells, another immune response pathway suspected to play a role in allergy and infection. The team showed that ILC2s signal information about the presence of allergens (such as house dust mite) or invading pathogens (such as Staphylococcus aureus) to the T-cells, but also trigger immune responses in unwanted contexts, such as in atopic eczema.
Importantly, these results suggest possible targets for future therapies. The team showed that the ILC2s can amplify subsequent immune responses by binding and presenting particular fat molecules, which can trigger an inflammation cascade “That cascade of inflammation can include the production of messenger molecules called cytokines. This offers the possibility of interfering with those cytokines for future treatment development.” explains Prof Ogg “Our next steps are to understand the nature of the fats that are triggering the immune cascade and the nature of the particular cytokines that the cells are producing, so that they might be modulated in future treatments.”
This work was supported by the NIHR Oxford Biomedical Research Centre, NIHR Comprehensive Research Network and the MRC.