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jakob.haldrupjensen@ndcls.ox.ac.uk

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Jakob Hansen Haldrup

Wellcome Trust Early Career Fellow & Junior Research Fellow (Wolfson College)

Traceless delivery of genome editing toolkits

My research in the Gene Medicine Group is focused on developing new vectors for delivery of genome editing toolkits, aiming to circumvent key issues with current viral and non-viral delivery strategies. By incorporation of ribonucleoprotein (RNP) complexes into lentiviral particles, the packaging limit is expanded and the cargo is delivered in a transient manner. My role as a Postdoctoral Research Scientist is to further harness the platform for therapeutic use in preclinical models of severe genetic defects in the pulmonary system.

Before joining the Gene Medicine Group, I worked as postdoctoral researcher at Department of Biomedicine, Aarhus University. My work included gene correction by base editing and prime editing with delivery via engineered nanoparticles. Prior to this, I obtained my PhD degree in Molecular Medicine and M.Sc. in Biological and Chemical Engineering at Aarhus University.