Martin Farrall
Emeritus Professor
I work with clinical groups to use both family and population-based studies to investigate the genetic component of complex cardiovascular and cerebrovascular diseases
- familial coronary artery disease (CAD) - PROCARDIS with Hugh Watkins and Rory Collins and with the CARDIoGRAMplusC4D Consortium
- inherited cardiomyopathies with Hugh Watkins
- ischemic stroke - WTCCC2 and METASTROKE with Peter Rothwell and Hugh Markus
- essential hypertension - MRC BRIGHT project and the Wellcome Trust Case Control Consortium (WTCCC1)
- pre-eclampsia - GOPEC and WTCCC3
- congenital heart disease - WTCCC3 with Shoumo Bhattacharya
Key publications
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A comprehensive 1,000 Genomes-based genome-wide association meta-analysis of coronary artery disease.
Journal article
Nikpay M. et al, (2015), Nat Genet, 47, 1121 - 1130
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Exome sequencing identifies rare LDLR and APOA5 alleles conferring risk for myocardial infarction.
Journal article
Do R. et al, (2015), Nature, 518, 102 - 106
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A genome-wide association study in Europeans and South Asians identifies five new loci for coronary artery disease.
Journal article
Coronary Artery Disease (C4D) Genetics Consortium None., (2011), Nat Genet, 43, 339 - 344
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Genetic variants associated with Lp(a) lipoprotein level and coronary disease.
Journal article
Clarke R. et al, (2009), N Engl J Med, 361, 2518 - 2528
Recent publications
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Data-driven modelling of mutational hotspots and in silico predictors in hypertrophic cardiomyopathy.
Journal article
Waring A. et al, (2021), J Med Genet, 58, 556 - 564
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Heritability and family-based GWAS analyses of the N-acyl ethanolamine and ceramide plasma lipidome.
Journal article
McGurk KA. et al, (2021), Hum Mol Genet, 30, 500 - 513
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Common genetic variants and modifiable risk factors underpin hypertrophic cardiomyopathy susceptibility and expressivity.
Journal article
Harper AR. et al, (2021), Nat Genet, 53, 135 - 142
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Common genetic variants and modifiable risk factors underpin hypertrophic cardiomyopathy susceptibility and expressivity.
Journal article
Harper AR. et al, (2021), Nat Genet, 53, 135 - 142
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Heritability of haemodynamics in the ascending aorta.
Journal article
McGurk KA. et al, (2020), Sci Rep, 10