Contact information
Research groups
Sarah Howles
DPhil, MRCS (Eng), MA (Cantab)
Academic Clinical Lecturer in Urology
I am a researcher and trainee in urological surgery. My research is based in the Oxford Centre for Diabetes, Endocrinology and Metabolism, Churchill Hospital, where I work as part of Professor Rajesh Thakker's group. I studied medicine at Cambridge and Oxford Universities between 1999 and 2005 and since qualification have worked in the Oxford region, entering the Urology training scheme in 2010. I was appointed as a Wellcome Trust clinical training fellow in 2011 and as an NIHR Academic Clinical Lecturer in Urology in 2015.Kidney stone disease is a common problem, affecting up to 20% of men and 10% of women by 70 years of age. Hypercalciuria is linked to an increased risk of forming such stones and my research focuses on trying to understand the tubular process regulating calcium excretion. My approach is to study monogenetic disorders causing either hypercalcaemia or hypercalciuria and identify the molecular pathways resulting in this phenotype.
Recent publications
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Matched pair analysis of wide versus narrow focus during shockwave lithotripsy for urolithiasis.
Sharp AJ. et al, (2024), Urolithiasis, 53
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Causal inference in health and disease: a review of the principles and applications of Mendelian randomization.
Lovegrove CE. et al, (2024), J Bone Miner Res
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Mucinous Adenocarcinoma of the Prostate With Normal Prostate-Specific Antigen Levels, Pulmonary Metastasis, and the Absence of Nodal Disease: A Case Report.
Khokhar AA. et al, (2024), Cureus, 16
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Urology Never Events in the UK. A retrospective 10-year review
Loyala V. et al, (2024), BJUI Compass
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Central Adiposity Increases Risk of Kidney Stone Disease via Effects on Serum Calcium Concentrations.
Lovegrove CE. et al, (2023), J Am Soc Nephrol
ORCID
0000-0002-1825-0097