Is nonangiogenesis a novel pathway for cancer progression? A study using 3-dimensional tumour reconstructions.
Adighibe O., Micklem K., Campo L., Ferguson M., Harris A., Pozos R., Gatter K., Pezzella F.
The nonangiogenic lung tumour is characterized by neoplastic cells co-opting the pre-existent vasculature and filling the alveoli space. 3-dimensional reconstruction of the tumour reveals that this particular tumour progresses without neovascularization and there is no major destruction of the lung's architectural integrity.