Joint patient and clinician priority setting to identify 10 key research questions regarding the long-term sequelae of COVID-19.
Houchen-Wolloff L., Poinasamy K., Holmes K., Tarpey M., Hastie C., Raihani K., Rogers N., Smith N., Adams D., Burgess P., Clark J., Cranage C., Desai M., Geary N., Gill R., Mangwani J., Staunton L., Berry C., Bolton CE., Chalder T., Chalmers J., De Soyza A., Elneima O., Geddes J., Heller S., Ho L-P., Jacob J., McAuley H., Parmar A., Quint JK., Raman B., Rowland M., Singapuri A., Singh SJ., Thomas D., Toshner MR., Wain LV., Horsley AR., Marks M., Brightling CE., Evans RA.
Given the large numbers of people infected and high rates of ongoing morbidity, research is clearly required to address the needs of adult survivors of COVID-19 living with ongoing symptoms (long COVID). To help direct resource and research efforts, we completed a research prioritisation process incorporating views from adults with ongoing symptoms of COVID-19, carers, clinicians and clinical researchers. The final top 10 research questions were agreed at an independently mediated workshop and included: identifying underlying mechanisms of long COVID, establishing diagnostic tools, understanding trajectory of recovery and evaluating the role of interventions both during the acute and persistent phases of the illness.