Geographic disparity in 10-year mortality after coronary artery revascularization in the SYNTAXES trial.
Kageyama S., Serruys PW., Garg S., Ninomiya K., Masuda S., Kotoku N., Colombo A., Mack MJ., Banning AP., Morice M-C., Witkowski A., Curzen N., Burzotta F., James S., van Geuns R-J., Davierwala PM., Holmes DR., Wood DA., McEvoy JW., Onuma Y., SYNTAX Extended Survival Investigators None.
AIMS: To investigate geographic disparity in long-term mortality following revascularization in patients with complex coronary artery disease (CAD). METHODS AND RESULTS: The SYNTAXES trial randomized 1800 patients with three-vessel and/or left main CAD to percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG) and assessed their survival at 10 years. Patients were stratified according to the region of recruitment: North America (N-A, n = 245), Eastern Europe (E-E, n = 189), Northern Europe (N-E, n = 425), Southern Europe (S-E, n = 263), and Western Europe (W-E, n = 678), which also served as the reference group. Compared to W-E, patients were younger in E-E (62 vs 65 years, p