Akbar Group: Extracellular Vesicles in Cardiovascular, Inflammatory and Metabolic Disease
The Akbar Lab is interested in defining the therapeutic and diagnostic potential of extracellular vesicles for immunomodulation and precision medicine in cardiovascular, metabolic, and inflammatory diseases.
We have a particular interest in how endothelial cell derived extracellular vesicles mediate long range communication across organs, and how we can capitalise on this signalling for targeted therapeutics and diagnosis. We employ state of the art techniques in extracellular vesicle isolation and characterisation, using translational approaches of highly characterised clinical cohorts to derive hypothesis driven in vitro and in vivo studies using model systems.
DPhil Students
Current
Dann Paget
Lewis Timms
Amaury Genovese
Complete
2019 Laurienne Edgar
Masters Students
Current
Amber Wilkins
Undergraduate Final Honours School Students
Current
Divya Ganesh
Complete
2022 Raphaella Ridley
2019 Charlotte Lee
2018 Jonathan Martin
2018 Eleanor Hogg
2017 Tanvir Rafe
Latest publications
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Impact of patient demographics on treatment outcomes in AML: a population-based registry in England, 2013-2020.
Journal article
Liu H. et al, (2024), Blood Adv
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Flow inefficiencies in non-obstructive HCM revealed by left ventricular kinetic energy and hemodynamic force analysis from 4D flow CMR
Journal article
Pola K. et al, (2024), European Heart Journal - Imaging Methods and Practice
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Discrete mechanistic pathways underlying genetic predisposition to atrial fibrillation are associated with different intermediate cardiac phenotypes and risk of cardioembolic stroke
Preprint
Gajendragadkar PR. et al, (2024)
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A Comparison of Structural Variant Calling from Short-Read and Nanopore-Based Whole-Genome Sequencing Using Optical Genome Mapping as a Benchmark
Journal article
Pei Y. et al, (2024), Genes, 15, 925 - 925