HLA-peptide tetrameric complexes.
Ogg GS., McMichael AJ.
HLA-peptide tetrameric complexes allow the direct ex vivo visualisation of antigen-specific CD8+ T cells and natural killer cells by flow cytometry. Quantitation, phenotypic analysis and isolation of tetramer-binding cells has considerably extended our understanding of cytotoxic T lymphocyte and natural killer cell function.