Promoter hypermethylation
Pellacani D., Packer RJ., Frame FM., Oldridge EE., Berry PA., Labarthe MC., Stower MJ., Simms MS., Collins AT., Maitland NJ.
© 2013 by Apple Academic Press, Inc. Epigenetic regulation of gene expression is a dynamic mechanism, which permits precise regulation throughout differentiation [1]. It plays a crucial role in preserving the hierarchical structure of tissues and is involved in maintaining stemness and fate determination of adult stem cells [2, 3]. Indeed, DNA methylation varies throughout cell differentiation [4] and epigenetic control is required for the multipotency of hematopoietic stem cells [5].