A human genome editing-based MLL::AF4 B-cell ALL model recapitulates key cellular and molecular leukemogenic features.
Bueno C., Torres-Ruíz R., Velasco-Hernandez T., Molina O., Petazzi P., Martinez-Moreno A., Rodríguez-Cortez VC., Vinyoles M., Cantilena S., Williams O., Vega-García N., Rodriguez-Perales S., Segovia JC., Quintana-Bustamante O., Roy A., Meyer C., Marschalek R., Smith A., Milne TA., Fraga MF., Tejedor JRR., Menendez P.
The cellular ontogeny and location of the MLL-breakpoint influence the capacity of MLL-edited CD34+ HSPCs to initiate pro-B-ALL, and recapitulate the molecular features of MLL-AF4+ infant B-ALL patients. We provide key insights into the cellular-molecular leukemogenic determinants of MLL-AF4+ infant B-ALL.