United Kingdom Prospective Diabetes Study (UKPDS Legacy Study)

OVERVIEW

UKPDS was a randomised, multicentre trial of glucose-lowering and antihypertensive therapies in patients with newly diagnosed type 2 diabetes. The study showed that complications of diabetes could be reduced by more intensive blood glucose and/or blood pressure control using existing treatments and dramatically changed the management of type 2 diabetes worldwide.

The UKPDS Legacy Study is an extended follow-up of UKPDS using electronic health records and other routinely collected health data.

DESIGN

The UKPDS Legacy Study intends to obtain updated forty-year follow-up data for the original participants of the UKPDS study by accessing electronic health record data via NHS Digital and NHS Scotland.

AIMS

To investigate whether early more intensive blood glucose and/or blood pressure control is associated with:

• A reduction in the risk of dementia
• A reduced risk of major vascular disease in the longer term

To assess the health economic impact of early more intensive blood glucose and/or blood pressure control over a lifetime horizon

FURTHER INFORMATION

If you were a UKPDS participant, you can read the privacy notice for the UKPDS Legacy study here.