DTU Publications (1970-1999)
1999
Hyperglycemia and hyperinsulinemia at diagnosis of diabetes and their association with subsequent cardiovascular disease in the United Kingdom prospective diabetes study (UKPDS 47).
Adler AI. et al, (1999), Am Heart J, 138, S353 - S359
Metformin and risk of cardiovascular disease.
Turner RC. and Holman RR., (1999), Cardiology, 91, 203 - 204
Microaneurysms in the development of diabetic retinopathy (UKPDS 42). UK Prospective Diabetes Study Group.
Kohner EM. et al, (1999), Diabetologia, 42, 1107 - 1112
A randomized double-blind trial of acarbose in type 2 diabetes shows improved glycemic control over 3 years (U.K. Prospective Diabetes Study 44)
Holman RR. et al, (1999), Diabetes Care, 22, 960 - 964
Glycemic control with diet, sulfonylurea, metformin, or insulin in patients with type 2 diabetes mellitus. Progressive requirement for multiple therapies (UKPDS 49)
Turner RC. et al, (1999), Journal of the American Medical Association, 281, 2005 - 2012
Genetic heterogeneity of autoimmune diabetes: age of presentation in adults is influenced by HLA DRB1 and DQB1 genotypes (UKPDS 43). UK Prospective Diabetes Study (UKPDS) Group.
Horton V. et al, (1999), Diabetologia, 42, 608 - 616
1998
Cost effectiveness analysis of improved blood pressure control in hypertensive patients with type 2 diabetes: UKPDS 40
Gray A., (1998), British Medical Journal, 317, 720 - 726
Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33)
Turner RC. et al, (1998), LANCET, 352, 837 - 853
Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34)
Turner RC. et al, (1998), LANCET, 352, 854 - 865
Assessing the potential for alpha-glucosidase inhibitors in prediabetic states.
Holman RR., (1998), Diabetes Res Clin Pract, 40 Suppl, S21 - S25
Changes in amylin and amylin-like peptide concentrations and beta-cell function in response to sulfonylurea or insulin therapy in NIDDM.
Rachman J. et al, (1998), Diabetes Care, 21, 810 - 816
UKPDS 26: Sulphonylurea failure in non-insulin-dependent diabetic patients over six years
Matthews DR. et al, (1998), Diabetic Medicine, 15, 297 - 303
Risk factors for coronary artery disease in non-insulin dependent diabetes mellitus: United Kingdom Prospective Diabetes Study (UKPDS: 23)
Turner RC. et al, (1998), BMJ, 316, 823 - 828
United Kingdom Prospective Diabetes Study, 30: diabetic retinopathy at diagnosis of non-insulin-dependent diabetes mellitus and associated risk factors.
Kohner EM. et al, (1998), Arch Ophthalmol, 116, 297 - 303
United Kingdom Prospective Diabetes Study 24: a 6-year, randomized, controlled trial comparing sulfonylurea, insulin, and metformin therapy in patients with newly diagnosed type 2 diabetes that could not be controlled with diet therapy. United Kingdom Prospective Diabetes Study Group.
(1998), Ann Intern Med, 128, 165 - 175
UKPDS 28: A randomized trial of efficacy of early addition of metformin in sulfonylurea-treated type 2 diabetes
Wright AD. et al, (1998), Diabetes Care, 21, 87 - 92
1997
The Fasting Hyperglycaemia Study: I. Subject identification and recruitment for a non-insulin-dependent diabetes prevention trial.
Hammersley MS. et al, (1997), Metabolism, 46, 44 - 49
The Fasting Hyperglycaemia Study: II. Randomized controlled trial of reinforced healthy-living advice in subjects with increased but not diabetic fasting plasma glucose.
Dyson PA. et al, (1997), Metabolism, 46, 50 - 55
UKPDS 25: autoantibodies to islet-cell cytoplasm and glutamic acid decarboxylase for prediction of insulin requirement in type 2 diabetes
Turner R. et al, (1997), LANCET, 350, 1288 - 1293
U.K. Prospective Diabetes Study 27: Plasma lipids and lipoproteins at diagnosis of NIDDM by age and sex
(1997), Diabetes Care, 20, 1683 - 1687
Approach to maintaining comparability of biochemical data during long-term clinical trials.
Cull CA. et al, (1997), Clin Chem, 43, 1913 - 1918
U.K. Prospective Diabetes Study 22. Effect of age at diagnosis on diabetic tissue damage during the first 6 years of NIDDM.
Davis TM. et al, (1997), Diabetes Care, 20, 1435 - 1441
Coronary heart disease and risk factors in NIDDM--experience from the United Kingdom Prospective Diabetes Study.
Turner RC. et al, (1997), Diabetologia, 40 Suppl 2, S121 - S122
UKPDS 20: plasma leptin, obesity, and plasma insulin in type 2 diabetic subjects.
Widjaja A. et al, (1997), J Clin Endocrinol Metab, 82, 654 - 657
1996
High prevalence of a missense mutation of the glucokinase gene in gestational diabetic patients due to a founder-effect in a local population.
Saker PJ. et al, (1996), Diabetologia, 39, 1325 - 1328
Hypertension in Diabetes Study IV. Therapeutic requirements to maintain tight blood pressure control.
(1996), Diabetologia, 39, 1554 - 1561
The UK Prospective Diabetes Study
Turner RC. and Holman RR., (1996), Annals of Medicine, 28, 439 - 444
Randomized controlled pilot trial of a hand-held patient-oriented, insulin regimen optimizer
Holman RR. et al, (1996), Medical Informatics, 21, 317 - 326
UKPDS 18: Estimated dietary intake in type 2 diabetic patients randomly allocated to diet, sulphonylurea or insulin therapy
Eeley EA. et al, (1996), DIABETIC MEDICINE, 13, 656 - 662
Frequency of hypoglycemic episodes during intensive therapy with human insulin.
Tubner RC. et al, (1996), Diabetes Care, 19, 181 - 182
United Kingdom Prospective Diabetes Study 17: a 9-year update of a randomized, controlled trial on the effect of improved metabolic control on complications in non-insulin-dependent diabetes mellitus.
Turner R. et al, (1996), Ann Intern Med, 124, 136 - 145
1995
UK prospective diabetes study (UKPDS) 14: association of angiotensin-converting enzyme insertion/deletion polymorphism with myocardial infarction in NIDDM.
Keavney BD. et al, (1995), Diabetologia, 38, 948 - 952
Lessons from UK prospective diabetes study.
Turner RC. and Holman RR., (1995), Diabetes Res Clin Pract, 28 Suppl, S151 - S157
Insulin therapy in type II diabetes.
Holman RR. and Turner RC., (1995), Diabetes Res Clin Pract, 28 Suppl, S179 - S184
1994
Optimized diabetes therapy knowledge-based systems: Safety critical issues
Nealon JL. et al, (1994), IEE Colloquium (Digest)
1993
Availability of type II diabetic families for detection of diabetes susceptibility genes.
Cook JT. et al, (1993), Diabetes, 42, 1536 - 1543
Hypertension in Diabetes Study (HDS): II. Increased risk of cardiovascular complications in hypertensive type 2 diabetic patients.
(1993), J Hypertens, 11, 319 - 325
1991
UK Prospective Diabetes Study (UKPDS). VIII. Study design, progress and performance.
(1991), Diabetologia, 34, 877 - 890
Post-prandial glycaemic reduction by an alpha-glucosidase inhibitor in type 2 diabetic patients with therapeutically attained basal normoglycaemia.
Holman RR. et al, (1991), Diabetes Res, 18, 149 - 153
Autoantibodies to islet amyloid polypeptide in diabetes.
Clark A. et al, (1991), Diabet Med, 8, 668 - 673
1990
Rapid restoration of normoglycaemia using intravenous insulin boluses.
Dunnett JM. et al, (1990), Diabetes Res, 15, 151 - 155
Insulin use in NIDDM. Rationale based on pathophysiology of disease.
Turner RC. and Holman RR., (1990), Diabetes Care, 13, 1011 - 1020
1988
Optimizing blood glucose control in type 2 diabetes: an approach based on fasting blood glucose measurements.
Holman RR. and Turner RC., (1988), Diabet Med, 5, 582 - 588
Islet amyloid, increased A-cells, reduced B-cells and exocrine fibrosis: quantitative changes in the pancreas in type 2 diabetes.
Clark A. et al, (1988), Diabetes Res, 9, 151 - 159
Finger-prick blood samples: full blood counts in general practice.
Holman R., (1988), Practitioner, 232, 988 - 991
Diabetes mellitus and anaesthesia. A survey of the peri-operative management of the patient with diabetes mellitus.
Dunnet JM. et al, (1988), Anaesthesia, 43, 538 - 542
1987
Sulphonylurea failure in type 2 diabetes: treatment with a basal insulin supplement.
Holman RR. et al, (1987), Diabet Med, 4, 457 - 462
Type II diabetes of early onset: a distinct clinical and genetic syndrome?
O'Rahilly S. et al, (1987), Br Med J (Clin Res Ed), 294, 923 - 928
Glycosylated haemoglobin measurement on blood samples taken by patients: an additional aid to assessing diabetic control.
Holman RR. et al, (1987), Diabet Med, 4, 71 - 73
Quantitative modelling of endocrine diseases as exemplified by diabetes.
Turner RC. et al, (1987), Clin Endocrinol (Oxf), 26, 107 - 116
No glycemic benefit from guar administration in NIDDM.
Holman RR. et al, (1987), Diabetes Care, 10, 68 - 71
[Treatment of non-insulin-dependent diabetes].
Turner RC. and Holman RR., (1987), Journ Annu Diabetol Hotel Dieu, 291 - 301
1986
Quantifying early diabetic retinopathy.
Howard-Williams JR. et al, (1986), Diabetologia, 29, 761 - 766
Diabetes nomenclature: classification or grading of severity?
Turner RC. et al, (1986), Diabet Med, 3, 216 - 220
Glycosylated haemoglobin: comparison of five different methods, including measurement on capillary blood samples.
Moore JC. et al, (1986), Ann Clin Biochem, 23 ( Pt 1), 85 - 91
1985
Continuous infusion of glucose with model assessment: measurement of insulin resistance and beta-cell function in man.
Hosker JP. et al, (1985), Diabetologia, 28, 401 - 411
Patient-orientated metered capillary blood collection.
Holman RR. et al, (1985), Ann Clin Biochem, 22 ( Pt 2), 141 - 143
Physiology of insulin secretion: problems of quantity and timing.
Matthews DR. et al, (1985), Neth J Med, 28 Suppl 1, 20 - 24
A practical guide to basal and prandial insulin therapy.
Holman RR. and Turner RC., (1985), Diabet Med, 2, 45 - 53
1984
Non-uniform distribution of islet amyloid in the pancreas of 'maturity-onset' diabetic patients.
Clark A. et al, (1984), Diabetologia, 27, 527 - 528
Insulin treatment of maturity onset diabetes.
Turner RC. and Holman RR., (1984), Minerva Endocrinol, 9, 233 - 240
1983
Prevention of deterioration of renal and sensory-nerve function by more intensive management of insulin-dependent diabetic patients. A two-year randomised prospective study.
Holman RR. et al, (1983), Lancet, 1, 204 - 208
1982
A regular meal and insulin infusion regimen: its use in the treatment of acute-onset ketotic diabetes and in stabilization of poorly controlled established diabetic subjects.
Davis TM. et al, (1982), Diabetes Care, 5, 492 - 496
Relative contributions of insulin deficiency and insulin resistance in maturity-onset diabetes.
Turner RC. et al, (1982), Lancet, 1, 596 - 598
Vibration sensory threshold: a guide to adequacy of dialysis?
Read DJ. et al, (1983), Proc Eur Dial Transplant Assoc, 19, 253 - 257
1981
The basal plasma glucose: a simple relevant index of maturity-onset diabetes.
Holman RR. and Turner RC., (1981), Clin Endocrinol (Oxf), 14, 279 - 286
1980
Fasting blood glucose concentrations and treatment of maturity-onset diabetes.
Howe-Davies S. et al, (1980), Br Med J, 280
Survival in sinoatrial disorder (sick-sinus syndrome).
Shaw DB. et al, (1980), Br Med J, 280, 139 - 141
1979
Insulin deficiency and insulin resistance interaction in diabetes: estimation of their relative contribution by feedback analysis from basal plasma insulin and glucose concentrations.
Turner RC. et al, (1979), Metabolism, 28, 1086 - 1096
A simple and rational twice daily insulin regime. Distinction between basal and meal insulin requirements.
Phillips M. et al, (1979), Q J Med, 48, 493 - 506
Maintenance of Basal Plasma Glucose and Insulin Concentrations in Maturity-Onset Diabetes
Holman RR. and Turner RC., (1979), Diabetes, 28, 227 - 230
1978
Home blood sampling for plasma glucose assay in control of diabetes.
Howe-Davies S. et al, (1978), Br Med J, 2, 596 - 598
Basal normoglycemia attained with chlorpropamide in mild diabetes.
Holman RR. and Turner RC., (1978), Metabolism, 27, 539 - 547
betacell function during insulin or chlorpropamide treatment of maturity-onset diabetes mellitus.
Turner RC. and Holman RR., (1978), Diabetes, 27 Suppl 1, 241 - 246
Serum lipids in treated diabetic children and their families.
Mann JI. et al, (1978), Clin Endocrinol (Oxf), 8, 27 - 33
1977
Diabetes: The quest for basal normoglycaemia.
Holman RR. and Turner RC., (1977), Lancet, 1, 469 - 474
Treatment of type IV hypertriglyceridaemia with insulin
Turner RC. et al, (1977), Clinical Science and Molecular Medicine, 53
1976
Insulin rather than glucose homoeostasis in the pathophysiology of diabetes.
Turner RC. and Holman RR., (1976), Lancet, 1, 1272 - 1274
Beta-cell function improved by supplementing basal insulin secretion in mild diabetes.
Turner RC. et al, (1976), Br Med J, 1, 1252 - 1254