Benoit Hastoy

I am currently a Diabetes UK R.D Lawrence Fellow at the Oxford Centre for Diabetes Endocrinology and Metabolism (OCDEM) and Scientific Director of the Centre for Artificial Intelligence in Precision Medicine (CAIPM). I investigate the impact of Type 2 Diabetes (T2D) risk genetic variants on pancreatic beta-cell secretory capacity and my collaborations through the CAIPM aim at developing small molecules that can rescue beta cell functions.

Type 2 Diabetes (T2D) is a complex disease involving the interaction between genetic and lifestyle factors. In T2D, β-cells do not secrete correct amount of insulin to reduce high blood-sugar levels after a meal. This defect can originate from the inability of β-cells to sense high blood sugar levels but also from their inability to deliver insulin. My fellowship focuses on the latter and the aim of my work is to identify the regulatory mechanisms supported by genes that are associated with T2D-risk. For this I use extensively the human beta cell line EndoC-βH1, and human primary islets when available.

Background: I started as a PhD student in Professor Jochen Lang's group in Bordeaux in 2008. My project was on the molecular mechanisms promoting exocytosis of insulin; more precisely, on the specific role of the transmembrane domain of the SNARE VAMP2 protein. I was also able to broaden my knowledge by interacting closely with researchers from different scientific backgrounds (biophysicians, bioinformaticians). In 2012, I moved to Oxford and joined Professor Patrik Rorsman's team for my first postdoctoral position. There, I learnt electrophysiology and broadened my skills on live cell imaging (i.e. calcium imaging). While involved in several collaborations, I characterised using electrophysiology the human beta-cell lines EndoC-betah1/-betah2. During this time, I also investigated the impact of T2D associated genes such as SOX4 on exocytosis. In January 2015, I joined Professors Anna Gloyn's and Mark McCarthy's teams as a postdoctoral researcher working on an MRC Experimental Challenge Grant (DIVA) awarded to Professors McCarthy, Gloyn, Karpe and Rorsman. As a member of the DIVA consortium, I investigated the cellular physiology that underlies genetic predisposition for diabetes such as those associated with PAM and SLC30A8 genes.