A: Example of a fibrosis severity heatmap using our recently developed Continous Indexing of Fibrosis (CIF). B: Individual image tiles receive a CIF score from 0 to 1 depending on the severity of reticulin fibrosis, with high scores assigned to tiles displaying increased fiber quantity, thickness and intersections. C-D: This analysis improves the diagnosis of blood cancer subtypes (myeloproliferative neoplasms [MPN]) and allows high risk fibrotic features to be detected at early timepoints and tracked in individual patients.
