Research groups
Colleges
Jeremy Tomlinson
MB BCh, PhD, FRCP
Professor of Metabolic Endocrinology
My work tries to better understand and treat metabolic diseases, in particular, non-alcholic fatty liver disease (NAFLD). Our work has focused on the role of steroid hormones and their metabolism in the development, assessment and treatment of metabolic diseases including NAFLD, obesity and type 2 diabetes. Our previous work has shown that altering steroid hormone metabolism can have a potent impact on the function of both liver and adipose tissue to store fat. Our future work will use steroid biomarkers not only to stage disease severity, but to predict progression. In addition, by altering tissue specific-metabolism, we hope to limit the side effects of prescribed steroids.
Key publications
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Dual-5α-Reductase Inhibition Promotes Hepatic Lipid Accumulation in Man.
Hazlehurst JM. et al, (2016), J Clin Endocrinol Metab, 101, 103 - 113
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Glucagon-like peptide 1 decreases lipotoxicity in non-alcoholic steatohepatitis.
Armstrong MJ. et al, (2016), J Hepatol, 64, 399 - 408
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5α-Reductase Type 2 Regulates Glucocorticoid Action and Metabolic Phenotype in Human Hepatocytes.
Nasiri M. et al, (2015), Endocrinology, 156, 2863 - 2871
Recent publications
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Prevalence and management of hypertension in Turner syndrome: data from the International Turner Syndrome (I-TS) registry.
Mathara Diddhenipothage SAD. et al, (2025), Endocr Connect, 14
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Randomised trial comparing weight loss through lifestyle and GLP-1 receptor agonist therapy in people with MASLD
Moolla A. et al, (2025), JHEP Reports, 101363 - 101363
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New Approaches to the Treatment of Hypercortisolism.
Pofi R. et al, (2025), Annu Rev Med, 76, 431 - 445
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Glucocorticoid treatment and new-onset hyperglycaemia and diabetes in people living with chronic obstructive pulmonary disease: A systematic review and meta-analysis.
Golubic R. et al, (2024), Diabet Med
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Lessons to learn from the 2024 NICE guideline on adrenal insufficiency.
Dong J. and Tomlinson JW., (2024), Lancet Diabetes Endocrinol