Websites
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Oxford Biobank
A cohort of healthy and T2D participants as a utility for translational research
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RDM Oxford Biobank
A cohort of healthy and T2D participants as a utility for translational research
Matt Neville
DPhil
Oxford Biobank Scientific Coordinator
I am the Oxford Biobank Scientific Coordinator, primarily responsible for curation of the Oxford Biobank (OBB) resources, facilitator of recruit-by-genotype and recruit-by-phenotype translational research studies available to the Metabolic Research Group (MRG), the larger research community and Industry and the management of all aspects of running the OBB facility. My primary research interests focus on understanding the genetic determinants of body fat function and distribution and how this may impact, and be utilised to improve, the health consequences of obesity. Other duties include primary genetic data interrogator and analyst for the MRG, DPhil student supervisor, Lecturer, marker and dissertation supervisor on the Experimental and Translational Therapeutics MSc program. I am a person designated (PD) for the OCDEM HTA license, and the RDM OCDEM EDI Champion.
I completed my DPhil in 2000 in human molecular genetics (Ox) followed by 2 years of R&D in industry (TWT, Madison, Wisconsin, US) working on marketable novel genetic assay systems. Previous research has included the contribution of genetics to smoking addiction and cessation within the General Practice Research group (Ox) and collaborations within the Department of Gastroenterology (Ox), imputing extended HLA haplotypes for association studies with autoimmune diseases such as Irritable Bowel Disease and Behçet's disease. In 2003 I took on a Postdoctoral Researcher position with Prof Fredrik Karpe investigating the genetics of Adipose tissue function and the adverse consequences of Obesity and Type II Diabetes. As a progression from these previous roles within the MRG and the Oxford Biobank I then took on the BRC funded position of Oxford Biobank Scientific Coordinator and manager in 2012.
Recent publications
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LRP5 promotes adipose progenitor cell fitness and adipocyte insulin sensitivity.
Loh NY. et al, (2025), Commun Med (Lond), 5
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Genetic determinants of monocyte splicing are enriched for disease susceptibility loci including for COVID-19
Fairfax B. et al, (2024)
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High-throughput mass spectrometry maps the sepsis plasma proteome and differences in patient response.
Mi Y. et al, (2024), Sci Transl Med, 16
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Characterization of the genetic determinants of context-specific DNA methylation in primary monocytes.
Gilchrist JJ. et al, (2024), Cell Genom
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Genome-wide characterization of circulating metabolic biomarkers.
Karjalainen MK. et al, (2024), Nature
ORCID
0000-0002-6004-5433