Research groups
Colleges
Patrik Rorsman
BM, PhD, FRS, FMedSci
Professor of Diabetic Medicine
Diabetes, Insulin secretion
We study the normal regulation of plasma glucose and how it becomes disrupted in diabetes. Our work focuses on the cells that secrete the plasma glucose-regulating hormones glucagon (that increases plasma glucose) and insulin (that lowers plasma glucose). In diabetes, insulin secretion is reduced and glucagon secretion increased. The aim of our work is to establish why these disturbances develop and if they can be corrected pharmacologically.
Recent publications
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The endoplasmic reticulum plays a key role in α-cell intracellular Ca2+ dynamics and glucose-regulated glucagon secretion in mouse islets.
Journal article
Acreman S. et al, (2024), iScience, 27
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An unclear role for the GLP-1 metabolite GLP-1(9–36) in human islet physiology. Reply to Matveyenko A, Vella A [letter]
Journal article
Gandasi NR. and Rorsman P., (2024), Diabetologia
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GLP-1 metabolite GLP-1(9-36) is a systemic inhibitor of mouse and human pancreatic islet glucagon secretion.
Journal article
Gandasi NR. et al, (2023), Diabetologia
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Glucose Controls Glucagon Secretion by Regulating Fatty Acid Oxidation in Pancreatic α-Cells.
Journal article
Armour SL. et al, (2023), Diabetes, 72, 1446 - 1459
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Platelet-derived lipids promote insulin secretion of pancreatic β cells.
Journal article
Karwen T. et al, (2023), EMBO Mol Med
ORCID
0000-0001-7578-0767