Contact information
Research groups
Sarah Howles
DPhil, MRCS (Eng), MA (Cantab)
Academic Clinical Lecturer in Urology
I am a researcher and trainee in urological surgery. My research is based in the Oxford Centre for Diabetes, Endocrinology and Metabolism, Churchill Hospital, where I work as part of Professor Rajesh Thakker's group. I studied medicine at Cambridge and Oxford Universities between 1999 and 2005 and since qualification have worked in the Oxford region, entering the Urology training scheme in 2010. I was appointed as a Wellcome Trust clinical training fellow in 2011 and as an NIHR Academic Clinical Lecturer in Urology in 2015.Kidney stone disease is a common problem, affecting up to 20% of men and 10% of women by 70 years of age. Hypercalciuria is linked to an increased risk of forming such stones and my research focuses on trying to understand the tubular process regulating calcium excretion. My approach is to study monogenetic disorders causing either hypercalcaemia or hypercalciuria and identify the molecular pathways resulting in this phenotype.
Recent publications
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Causal inference in health and disease: a review of the principles and applications of Mendelian randomization.
Journal article
Lovegrove CE. et al, (2024), J Bone Miner Res
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Mucinous Adenocarcinoma of the Prostate With Normal Prostate-Specific Antigen Levels, Pulmonary Metastasis, and the Absence of Nodal Disease: A Case Report.
Journal article
Khokhar AA. et al, (2024), Cureus, 16
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Urology Never Events in the UK. A retrospective 10-year review
Journal article
Loyala V. et al, (2024), BJUI Compass
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Central Adiposity Increases Risk of Kidney Stone Disease via Effects on Serum Calcium Concentrations.
Journal article
Lovegrove CE. et al, (2023), J Am Soc Nephrol
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Cinacalcet reverses short QT interval in Familial Hypocalciuric Hypercalcemia type 1
Journal article
Cuny T. et al, (2023), The Journal of Clinical Endocrinology & Metabolism
ORCID
0000-0002-1825-0097