Shoumo Bhattacharya
Professor of Cardiovascular Medicine
- Honorary Consultant Cardiologist
Shoumo Bhattacharya is Professor of Cardiovascular Medicine in the RDM Division of Cardiovascular Medicine at the University of Oxford and is based at the Wellcome Trust Centre for Human Genetics. He read medicine at the All India Institute of Medical Sciences in New Delhi, and trained in cardiology at Northwick Park and Hammersmith Hospitals in London, where he was also a MRC Training Fellow with James Scott working on RNA editing. He followed this with BHF and NIH Fellowships at the Dana-Farber Cancer Institute with David Livingston working on transcription factor protein interactions. He was a Wellcome Trust Senior Fellow at Oxford from 1998 to 2008, working on the transcriptional control of heart development, and their role in left-right patterning. He was elected Fellow of the Royal College of Physicians in 2003, awarded the Graham Bull Prize from the Royal College of Physicians in 2005, elected Fellow of the Academy of Medical Sciences in 2006. He was awarded a BHF Chair in 2009, and elected to a statutory Professorship at the University of Oxford in 2010. His primary role as BHF Chair has been the development of novel therapeutics and targets. The major focus of his lab is now the development of anti-inflammatory peptide therapeutics isolated from tick saliva that may have applications to myocarditis, post-myocardial infarction injury and myocardial fibrosis
Key publications
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Discovery and pharmacophoric characterization of chemokine network inhibitors using phage-display, saturation mutagenesis and computational modelling.
Journal article
Vales S. et al, (2023), Nat Commun, 14
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Evasins: Tick Salivary Proteins that Inhibit Mammalian Chemokines.
Journal article
Bhusal RP. et al, (2020), Trends Biochem Sci, 45, 108 - 122
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A knottin scaffold directs the CXC-chemokine-binding specificity of tick evasins.
Journal article
Lee AW. et al, (2019), J Biol Chem, 294, 11199 - 11212
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The N-terminal domain of a tick evasin is critical for chemokine binding and neutralization and confers specific binding activity to other evasins.
Journal article
Eaton JRO. et al, (2018), J Biol Chem, 293, 6134 - 6146
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Genetically engineered two-warhead evasins provide a method to achieve precision targeting of disease-relevant chemokine subsets.
Journal article
Alenazi Y. et al, (2018), Sci Rep, 8
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Yeast surface display identifies a family of evasins from ticks with novel polyvalent CC chemokine-binding activities.
Journal article
Singh K. et al, (2017), Sci Rep, 7
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VACTERL/caudal regression/Currarino syndrome-like malformations in mice with mutation in the proprotein convertase Pcsk5.
Journal article
Szumska D. et al, (2008), Genes Dev, 22, 1465 - 1477
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Cardiac malformations, adrenal agenesis, neural crest defects and exencephaly in mice lacking Cited2, a new Tfap2 co-activator.
Journal article
Bamforth SD. et al, (2001), Nat Genet, 29, 469 - 474
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Cited2 controls left-right patterning and heart development through a Nodal-Pitx2c pathway.
Journal article
Bamforth SD. et al, (2004), Nat Genet, 36, 1189 - 1196
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Functional role of p35srj, a novel p300/CBP binding protein, during transactivation by HIF-1.
Journal article
Bhattacharya S. et al, (1999), Genes Dev, 13, 64 - 75
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Cooperation of Stat2 and p300/CBP in signalling induced by interferon-alpha.
Journal article
Bhattacharya S. et al, (1996), Nature, 383, 344 - 347
Recent publications
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Mutagenesis on a complex mouse genetic background by site-specific nucleases.
Journal article
Davies B. et al, (2024), Transgenic Res
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Discovery and pharmacophoric characterization of chemokine network inhibitors using phage-display, saturation mutagenesis and computational modelling.
Journal article
Vales S. et al, (2023), Nat Commun, 14
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Calcitonin paracrine signaling controls heart fibrogenesis and arrhythmia
Conference paper
Moreira L. et al, (2022), JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 173, S85 - S86
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Author Correction: Yeast surface display identifies a family of evasins from ticks with novel polyvalent CC chemokine-binding activities.
Journal article
Singh K. et al, (2021), Sci Rep, 11
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Phylogenetic Analysis Indicates That Evasin-Like Proteins of Ixodid Ticks Fall Into Three Distinct Classes.
Journal article
Bhattacharya S. and Nuttall PA., (2021), Front Cell Infect Microbiol, 11
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Transcriptomic Analysis of Inflammatory Cardiomyopathy Identifies Molecular Signatures of Disease and Informs in silico Prediction of a Network-Based Rationale for Therapy.
Journal article
Singh K. et al, (2021), Front Immunol, 12
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Calcitonin paracrine signaling controls atrial fibrogenesis and arrhythmia
Journal article
MOREIRA LM. et al, (2020), Nature
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Engineered anti-inflammatory peptides inspired by mapping an evasin-chemokine interaction.
Journal article
Darlot B. et al, (2020), J Biol Chem, 295, 10926 - 10939
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Early Embryonic Expression of AP-2α Is Critical for Cardiovascular Development.
Journal article
Johnson A-L. et al, (2020), J Cardiovasc Dev Dis, 7
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Characterization of a novel inhibitor of coagulation factor XIa identified from salivary gland transcripts of the lone star tick, Amblyomma americanum.
Journal article
Mrinalini None. et al, (2020), Toxicon, 177 Suppl 1