Tanja Davis
BSc (Hons); MSc; PhD
Postdoctoral Researcher
I completed BSc (Hons) and MSc degrees in Genetics and followed with a PhD in Physiology at Stellenbosch University, South Africa. I subsequently undertook a postdoctoral fellowship with Prof Willem de Villers at Stellenbosch University, investigating the role of the acute-phase protein serum amyloid A in colitis-associated colon cancer.
I have a passion for cancer research and my interests include the tumour microenvironment, specifically interactions with the innate immune system. This has led me to join the group of Prof Jan Rehwinkel in 2021, where my current research focuses on SAMHD1 and its role in activating innate immune sensing in a cancer setting.
Recent publications
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Adenosine-to-inosine editing of endogenous Z-form RNA by the deaminase ADAR1 prevents spontaneous MAVS-dependent type I interferon responses.
Journal article
Tang Q. et al, (2021), Immunity, 54, 1961 - 1975.e5
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Molecular regulation of autophagy in a pro-inflammatory tumour microenvironment: New insight into the role of serum amyloid A.
Journal article
du Plessis M. et al, (2021), Cytokine & growth factor reviews, 59, 71 - 83
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Mechanisms of doxorubicin-induced drug resistance and drug resistant tumour growth in a murine breast tumour model.
Journal article
Christowitz C. et al, (2019), BMC cancer, 19
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The paracrine effects of fibroblasts on Doxorubicin-treated breast cancer cells.
Journal article
Fourie C. et al, (2019), Experimental cell research, 381, 280 - 287
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How Does Inflammation-Induced Hyperglycemia Cause Mitochondrial Dysfunction in Immune Cells?
Journal article
van Niekerk G. et al, (2019), BioEssays : news and reviews in molecular, cellular and developmental biology, 41