portrait
Research groups
Colleges
Yi-Ling Chen
DPhil
Career Development Fellow
Research Summary
I joined the lab of Professor Graham Ogg as a DPhil student in 2014 to investigate the immune networks in human cutaneous inflammation and the translational development of novel therapeutic approaches. My work has been focusing on understanding the interaction and modulation of key innate immune cells in inflammatory conditions, and to identify novel therapeutic targets in sterile skin inflammation and cutaneous and systemic bacterial infection. Since completing my DPhil, I continued my research as a Postdoctoral researcher, expanding my expertise and investigating the role of unconventional T cells in skin infectious and inflammatory diseases, adopting high-dimensional approaches and T cell cloning techniques. I have started my group as a career development fellow at the beginning of 2023 to focus on the role of CD1c-reactive T cells in tissue homeostasis and microbial defence.
Recent publications
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Unconventional human CD61 pairing with CD103 promotes TCR signaling and antigen-specific T cell cytotoxicity.
Journal article
Hamid MHBA. et al, (2024), Nat Immunol
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A high-throughput two-cell assay for interrogating inhibitory signaling pathways in T cells.
Journal article
Sharma S. et al, (2024), Life Sci Alliance, 7
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Group A Streptococcus induces CD1a-autoreactive T cells and promotes psoriatic inflammation.
Journal article
Chen Y-L. et al, (2023), Sci Immunol, 8
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Staphylococcal phosphatidylglycerol antigens activate human T cells via CD1a.
Journal article
Monnot GC. et al, (2022), Nat Immunol
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CD1a promotes systemic manifestations of skin inflammation.
Journal article
Hardman CS. et al, (2022), Nat Commun, 13