The genome-wide impact of trisomy 21 on DNA methylation and its implications for hematopoiesis.
Muskens IS., Li S., Jackson T., Elliot N., Hansen HM., Myint SS., Pandey P., Schraw JM., Roy R., Anguiano J., Goudevenou K., Siegmund KD., Lupo PJ., de Bruijn MFTR., Walsh KM., Vyas P., Ma X., Roy A., Roberts I., Wiemels JL., de Smith AJ.
Down syndrome is associated with genome-wide perturbation of gene expression, which may be mediated by epigenetic changes. We perform an epigenome-wide association study on neonatal bloodspots comparing 196 newborns with Down syndrome and 439 newborns without Down syndrome, adjusting for cell-type heterogeneity, which identifies 652 epigenome-wide significant CpGs (P