CTEPH is an uncommon complication of COVID-19: UK national surveillance and observational screening cohort studies.
Reddy SA., Newman J., Leavy OC., Ghani H., Pepke-Zaba J., Cannon JE., Sheares KK., Taboada D., Bunclark K., Lawrie A., Sudlow CL., Berry C., Wild JM., Mitchell JA., Quint J., Rossdale J., Price L., Howard LS., Wilkins M., Sattar N., Chowienczyk P., Thompson R., Wain LV., Horsley A., Ho L-P., Chalmers JD., Marks M., Poinasamy K., Raman B., Harris VC., Houchen-Wolloff L., Brightling CE., Evans RA., Toshner MR., PHOSP-COVID Study Collaborative Group None.
INTRODUCTION: Pulmonary embolism (PE) is a well-recognised complication of COVID-19 infection, and chronic thromboembolic pulmonary disease with and without pulmonary hypertension (CTEPD/CTEPH) are potential life-limiting consequences. At present the burden of CTEPD/CTEPH is unclear and optimal and cost-effective screening strategies yet to be established. METHODS: We evaluated the CTEPD/CTEPH referral rate to the UK national multidisciplinary team (MDT) during the 2017-2022 period to establish the national incidence of CTEPD/CTEPH potentially attributable to COVID-19-associated PE with historical comparator years. All individual cases of suspected CTEPH were reviewed by the MDT for evidence of associated COVID-19. In a separate multicentre cohort, the risk of developing CTEPH following hospitalisation with COVID-19 was calculated using simple clinical parameters at a median of 5 months post hospital discharge according to existing risk scores using symptoms, ECG and NT pro-BNP. RESULTS: By the second year of the pandemic, CTEPH diagnoses had returned to the pre-pandemic baseline (23.1 versus 27.8 cases per month, p=0.252). Of 334 confirmed CTEPD/CTEPH cases, 4 (1.2%) patients were identified to have CTEPH potentially associated with COVID-19 PE, and a further 3 (0.9%) CTEPD without PH. Of 1094 patients (mean age 58 years, 60.4% male) hospitalised with COVID-19 screened across the UK, 11 (1.0%) were at high risk of CTEPH at follow-up, none of whom had a diagnosis of CTEPH made at the national MDT. CONCLUSION: A-priori risk of developing CTEPH following COVID-19-related hospitalisation is low. Simple risk scoring is a potentially effective way of screening patients for further investigation.