Publications — Radcliffe Department of Medicine

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AnALPK3truncation variant causing autosomal dominant hypertrophic cardiomyopathy is partially rescued by mavacamten

Leinhos L. et al, (2024)

Hif-2α programmes oxygen chemosensitivity in chromaffin cells.

Prange-Barczynska M. et al, (2024), J Clin Invest

Mutagenesis on a complex mouse genetic background by site-specific nucleases.

Davies B. et al, (2024), Transgenic Res

Novel Role of 5-Methyl-(6S)-Tetrahydrofolate in Mediating Endothelial Cell Tetrahydrobiopterin in Pregnancy and Implications for Gestational Hypertension.

Dickinson Y. et al, (2024), Hypertension

Role of Human Epicardial Adipose Tissue-Derived miR-92a-3p in Myocardial Redox State.

Carena MC. et al, (2023), J Am Coll Cardiol, 82, 317 - 332

Cardiomyocyte tetrahydrobiopterin synthesis regulates fatty acid metabolism and susceptibility to ischaemia-reperfusion injury.

Chu SM. et al, (2023), Exp Physiol, 108, 874 - 890

Crucial neuroprotective roles of the metabolite BH4 in dopaminergic neurons.

Cronin SJF. et al, (2023), bioRxiv

Endothelial cell-specific roles for tetrahydrobiopterin in myocardial function, cardiac hypertrophy, and response to myocardial ischemia-reperfusion injury.

Chuaiphichai S. et al, (2023), Am J Physiol Heart Circ Physiol, 324, H430 - H442

PHACTR1 modulates vascular compliance but not endothelial function: a translational study.

Wood A. et al, (2023), Cardiovasc Res, 119, 599 - 610

Endothelial cell vasodilator dysfunction mediates progressive pregnancy-induced hypertension in endothelial cell tetrahydrobiopterin deficient mice.

Chuaiphichai S. et al, (2023), Vascul Pharmacol, 150

Insights into the Role of a Cardiomyopathy-Causing Genetic Variant in ACTN2.

Broadway-Stringer S. et al, (2023), Cells, 12

Human epicardial adipose tissue-secreted miR-92a-3p regulates myocardial redox state via paracrine signalling: implications for cardiovascular clinical outcomes

Badi I. et al, (2023), EUROPEAN HEART JOURNAL, 44

Crucial functions of alpha-actinin 2 in the embryonic heart

Gehmlich K. et al, (2022), CARDIOVASCULAR RESEARCH, 118

Deletion of tetrahydrobiopterin synthesis in cardiomyocytes causes downregulation of fatty acid metabolism whilst protected against cardiac ischemia reperfusion injury

Chu S. et al, (2022), JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 173, S125 - S125

Endothelial GTPCH (GTP Cyclohydrolase 1) and Tetrahydrobiopterin Regulate Gestational Blood Pressure, Uteroplacental Remodeling, and Fetal Growth.

Chuaiphichai S. et al, (2021), Hypertension

Developmental role of PHD2 in the pathogenesis of pseudohypoxic pheochromocytoma.

Eckardt L. et al, (2021), Endocr Relat Cancer, 28, 757 - 772

A key role for the novel coronary artery disease gene JCAD in atherosclerosis via shear stress mechanotransduction.

Douglas G. et al, (2020), Cardiovasc Res, 116, 1863 - 1874

Insulin-induced vascular redox dysregulation in human atherosclerosis is ameliorated by dipeptidyl peptidase 4 inhibition.

Akoumianakis I. et al, (2020), Sci Transl Med, 12

Adipose tissue-derived WNT5A regulates vascular redox signaling in obesity via USP17/RAC1-mediated activation of NADPH oxidases.

Akoumianakis I. et al, (2019), Sci Transl Med, 11

Nox2 contributes to age-related oxidative damage to neurons and the cerebral vasculature.

Fan LM. et al, (2019), J Clin Invest, 130

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