Search results
Found 27 matches for
Zimmermann Group: Iron Nutrition - Stable Isotopes and Therapeutics
The overall aim of our research program is to improve iron nutrition and reduce anaemia in women and children, directly supporting the U.N.'s 2030 Sustainable Development Goal of ‘Zero Hunger’.
Koohy Group: Machine Learning and Integrative Approaches in Immunology
- Investigative Medicine Division
- MRC Translational Immune Discovery Unit
- MRC Weatherall Institute of Molecular Medicine
We would like to understand the functional and molecular mechanisms of the immune system in various immunologically important conditions such as cancer, infection, autoimmune disease as well as ageing. We have a special interest in computational cancer immunotherapy such as antigen presentation,…
Wilkinson Group: Blood Stem Cell Expansion and Fitness
Haematopoietic stem cells (HSCs) support blood cell production throughout life and are also used clinically in cell and gene therapies. We are studying the biology of this important stem cell population with the aim of developing new HSC-based therapies.
Simmons Group: Intestinal Immunity in Health and Disease
We define how the immune system functions in the intestine to promote health. We uncover the immune pathogenesis of intestinal diseases such as inflammatory bowel disease to develop better ways to treat these disorders.
Chakraverty Group: Haematopoietic Transplantation and Immunotherapy
- MRC Molecular Haematology Unit
- MRC Weatherall Institute of Molecular Medicine
- Nuffield Division of Clinical Laboratory Sciences
Our group is interested in developing novel immunotherapeutic approaches for leukaemia. Clinical approaches currently used include allogeneic haematopoietic stem cell transplantation, chimeric antigen receptor T cell therapy and immune checkpoint inhibitors. While each of these approaches can…
Psaila Group: The tumour microenvironment in blood cancers
- MRC Molecular Haematology Unit
- MRC Weatherall Institute of Molecular Medicine
- Nuffield Division of Clinical Laboratory Sciences
We focus on four key areas: (1) Dissecting how blood cancers create 'self-reinforcing' niches that promote clonal expansion and protect malignant clones from immunotherapies; (2) Development and application of human bone marrow organoids to study normal and malignant haematopoiesis and validate tar…
Davies Group: Genomics and Clinical Genome Editing
- MRC Molecular Haematology Unit
- MRC Weatherall Institute of Molecular Medicine
- Nuffield Division of Clinical Laboratory Sciences
We are primarily interested in understanding how the genome functions and to leverage this to develop novel genome editing based cellular therapies
Patel Group: Two tier protection and metabolic genotoxicity during blood production
We study endogenous DNA damage caused by metabolites and their impact on the function of vertebrate stem cells and the ageing process
Sims Group: Computational Genomics
We are a computational biology research group using genomic and functional genomic data to study transcriptional regulation, with projects spanning from neuroscience to musculoskeletal biology.
Sauka-Spengler Group: Gene Regulatory Networks in Development and Disease
We focus on systems level “big picture” approaches to understand gene regulation and build gene regulatory networks during development and disease in zebrafish, chick, lamprey and human models.
Jackson Group: Lymphatic Trafficking Research Group
- Investigative Medicine Division
- MRC Translational Immune Discovery Unit
- MRC Weatherall Institute of Molecular Medicine
We focus on the mechanisms controlling the migration of leucocytes and tumour cells via lymph in health and disease.
de Bruijn Group: Developmental Haematopoiesis
- MRC Molecular Haematology Unit
- MRC Weatherall Institute of Molecular Medicine
- Nuffield Division of Clinical Laboratory Sciences
We study the embryonic origins of blood stem cells with the aim to inform the generation of these cells in culture, and ultimate produce clinically relevant blood stem cells for therapeutic purposes.
Higgs Group: Laboratory of Gene Regulation
We use state-of-the-art laboratory and computational approaches to understand how mammalian genes are switched on and off during development and differentiation and how this goes awry in human genetic diseases.
Davis Group: T-cell Biology
- Investigative Medicine Division
- MRC Translational Immune Discovery Unit
- MRC Weatherall Institute of Molecular Medicine
We are interested in how lymphocytes decide to mount immune responses against, for example, tumours. This involves trying to understanding how leukocyte receptors, such as the T-cell receptor and immune checkpoints, are triggered.
Mead Group: Haematopoietic Stem Cell Biology
- MRC Molecular Haematology Unit
- MRC Weatherall Institute of Molecular Medicine
- Nuffield Division of Clinical Laboratory Sciences
The Haematopoietic Stem Cell Biology (HSCB) Laboratory is focused on understanding how the normal haematopoietic stem/progenitor hierarchy is disrupted during the development of myeloid malignancies. Our overarching aim is to improve the management of myeloproliferative neoplasms and related conditio…
Vyas Group: Biology and Treatment of Human Myeloid Cancers
- MRC Molecular Haematology Unit
- MRC Weatherall Institute of Molecular Medicine
- Nuffield Division of Clinical Laboratory Sciences
We aim to understand the fundamental biological processes underlying normal and malignant haematopoiesis and translate this to improve patient outcomes through new rational therapies.
Hughes Group: Genome Biology
- MRC Molecular Haematology Unit
- MRC Weatherall Institute of Molecular Medicine
- Nuffield Division of Clinical Laboratory Sciences
Using genomics, computational and synthetic biology approaches to understand how genes are regulated in health and disease.